Taxim-O/Taxim-O 400/Taxim-O Kids Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cefixime trihydrate

Indications/Uses

Otitis, media, bronchitis, UTI, pharyngitis, bronchitis. Taxim-O Otitis media & other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics, or where treatment failure may carry significant risk; cystitis, cystourethritis, uncomplicated pyelonephritis. Taxim-O 400 UTI caused by E. coli & Proteus mirabilis; uncomplicated gonorrhea caused by N. gonorrhoeae; otitis media caused by H. influenzae (β-lactamase +ve & -ve strains), Moraxella (Branhamella) catarrhalis, (most of which are β-lactamase +ve) & Strep pyogenes; tonsillitis, caused by Strep pyogenes. Taxim-O Kids Gonorrhea.

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Dosage/Direction for Use

Taxim-O Adult & childn >10 yr 200-400 mg daily according to the severity of infection as a single dose or in 2 divided doses for 7-14 days. Renal impairment (CrCl <20 mL/min) & patients who are maintained on chronic ambulatory peritoneal dialysis or haemodialysis 200 mg once daily. Taxim-O 400 Adult 200-400 mg as a single dose or in 2 divided doses. Uncomplicated cervical/urethral gonococcal infections 400 mg as a single oral dose. Childn 8 mg/kg/day as a single daily dose or in 2 divided doses. Childn weighing >50 kg or >12 yr Adult dose. Renal impairment (CrCl 21-60 mL/min) or patients who are on renal hemodialysis 75% of the standard dose at the standard dosing interval (300 mg daily), CrCl <20 mL/min or patients who are on continuous ambulatory peritoneal dialysis ¹/₂ the standard dosage at the standard dosing interval (200 mg daily.) Taxim-O Kids Childn 5-10 yr 200 mg daily, 1-4 yr 100 mg daily, 6 mth-1 yr 75 mg daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity to cefixime, cephalosporins or penicillins. Taxim-O 400 Pseudomembranous colitis.

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Special Precautions

Taxim-O Discontinue treatment when severe cutaneous adverse reactions occur. Drug-induced hemolytic anemia. Renal impairment. Premature or newborn infant. Taxim-O 400 Patients on dialysis. History of GI disease particularly colitis. Risk of fall in prothrombin activity in patients w/ renal/hepatic impairment, poor nutritional state or those receiving protracted course of antimicrobial therapy.

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Use In Pregnancy & Lactation

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Adverse Reactions

Eosinophilia; agranulocytosis; hemolytic anemia; leukopenia, thrombocytopenia, neutropenia; abdominal pain, dyspepsia, nausea, vomiting, diarrhea; pseudomembranous colitis; increased ALT/AST, blood bilirubin, blood urea, blood creatinine; jaundice; dizziness; anaphylactic/anaphylactoid reactions; skin rashes; serum sickness-like reactions; pruritus, genital pruritus; headache; drug fever; SJS, TEN, angioedema, urticaria, vaginitis; erythema multiforme; face edema. Taxim-O Granulocytopenia, thrombocytosis; flatulence; dyspnea; renal failure including tubulointerstitial nephritis; DRESS, arthralgia, pyrexia. Taxim-O 400 Loose stools; hepatitis; acute renal failure; seizures; hyperbilirubinemia; candidiasis. Taxim-O Kids bleeding complications related to hypoprothrombinemia &/or platelet dysfunction.

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Drug Interactions

Increased prothrombin time & enhance effects of the anticoagulants w/ anticoagulants. False +ve reaction for glucose in the urine w/ Benedict's or Fehling's soln or w/ Cu sulfate test tab; Coombs' test. Taxim-O 400 Elevates the levels of carbamazepine.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Taxim-O/Taxim-O 400/Taxim-O Kids detailed prescribing information

Storage

View Taxim-O/Taxim-O 400/Taxim-O Kids storage conditions for details to ensure optimal shelf-life.

Description

View Taxim-O/Taxim-O 400/Taxim-O Kids description for details of the chemical structure and excipients (inactive components).

Action

View Taxim-O/Taxim-O 400/Taxim-O Kids mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Cephalosporins

ATC Classification

J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Taxim-O FC tab 200 mg

Packing/Price

10's;50's

Form

Taxim-O 400 orodispersible tab 400 mg

Packing/Price

100's;30's

Form

Taxim-O Kids powd for oral susp 100 mg/5 mL

Packing/Price

60 mL x 1's

Taxim-O/Taxim-O 400/Taxim-O Kids

cefixime

Manufacturer:

Alkem Lab

Distributor:

Alkem Lab